In Vivo Mass Spectrometry with the LAESI DP-1000 System: A New Tool for Native Biomolecular Profiling and Biomarker Discovery

In vivo mass spectrometry of living cells has until recently been an unattainable goal due to several limitations from other techniques, including the requirement of a matrix, vacuum, and the ability to only analyze the surface of a sample. The ambient ionization technique, laser ablation electrospray ionization (LAESI), has facilitated the identification and characterization of biomolecules in living cells at ambient pressures, without the need for the addition of a matrix. This analysis allows researchers to obtain a direct representation of a living population by analyzing the biodynamics of molecules as they are in living samples at the point of analysis, without any sample handling.





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