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Label-Free Quantitation of Proteins in Human Prostate Cancer Patient Plasma

Protea's LC-MS Services team is focused on providing comprehensive toolsets that provide the ability to not only identify, but to simultaneously quantify protein biomarkers. In addition, the ability to compare quantitative differences in identified biomarkers between patient groups or treatment regimens provides an additional level of value and insight to today's researchers and clinicians. Together, these abilities provide a means for analysis of complex datasets and an expedited mechanism for determining protein biomarkers that show interesting differential behaviors.

This case study evaluates the accuracy and precision of label-free quantitation of standard proteins in a mixture. In addition, the label-free protein quantitation method was applied to a real world scenario: the analysis and quantitative comparison of the proteomes in human plasma from normal, early stage, and late stage prostate cancer patients.

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