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LAESI-MS vs MALDI-MS Imaging: Lipid Imaging from Mouse Brains

Laser Ablation Electrospray Ionization Mass Spectrometry (LAESI-MS) is a powerful technique for the direct imaging analysis of frozen tissue sections at atmospheric pressure. The Protea LAESI DP-1000 is a direct ionization system that uses LAESI technology combined with an advanced translational stage for molecular mapping. The LAESI DP- 1000 uses a mid-infrared (MIR) laser (2.94 μm) that is readily absorbed by water containing species to generate gas phase, neutral molecules. Ionization is achieved by capturing the ablated plume of sample with an electrospray ionization (ESI) plume located above the sample. The LAESI DP-1000 can directly analyze watercontaining samples, e.g. frozen tissue sections, without additional sample preparation beyond cryosectioning. This allows for faster sample analysis in addition to simplified methods and protocols.

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