MS Imaging Resources

High Throughput Screening of Urine Marker Codes by Laser Ablation Electrospray Ionization Mass Spectrometry (LAESI MS)

High throughput screening of targeted compounds in complex matrices is a task that is traditionally performed using LC-MS. However, even with the most optimized methodology, chromatographic separations typically require several minutes in addition to sample preparation processes, which also add time and material costs. Alternatives to LC-MS for certain applications would be beneficial to provide higher throughput screening of biological samples to reduce instrument usage and time. Laser ablation electrospray ionization (LAESI) is a direct analysis, ambient ionization source that interfaces to a variety of types of mass spectrometers and can be used to screen for target compounds within complex matrices.





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