Histology Guided Mass Spectrometry: A New Analytical Workflow for Clinical Research and Biomarker Discovery
Visualizing the morphology of tissue sections can provide a wealth of information regarding the overall health and disease state of the tissue or individual. This visual analysis is dependent on a pathologist to correctly identify regions of normal and diseased tissue. We have adapted a workflow to combine the optical observations with targeted chemical composition analysis by mass spectrometry. This hybrid analytical approach, Histology Guided Mass Spectrometry (HGMS™), allows targeted analysis of specific morphologies of the sample, providing chemical information associated to optical analysis.